Merlin weaves its magic on peripheral nerve repair
نویسندگان
چکیده
منابع مشابه
Merlin weaves its magic on peripheral nerve repair
Tumor suppressor helps reprogram Schwann cells to promote peripheral nerve regeneration.
متن کاملPeripheral nerve injury and repair.
Peripheral nerve injuries are common, and there is no easily available formula for successful treatment. Incomplete injuries are most frequent. Seddon classified nerve injuries into three categories: neurapraxia, axonotmesis, and neurotmesis. After complete axonal transection, the neuron undergoes a number of degenerative processes, followed by attempts at regeneration. A distal growth cone see...
متن کاملEngineered neural tissue for peripheral nerve repair.
A new combination of tissue engineering techniques provides a simple and effective method for building aligned cellular biomaterials. Self-alignment of Schwann cells within a tethered type-1 collagen matrix, followed by removal of interstitial fluid produces a stable tissue-like biomaterial that recreates the aligned cellular and extracellular matrix architecture associated with nerve grafts. S...
متن کاملExperimental Approaches on Tissue Engineering Repair of Peripheral Nerve Gaps
Peripheral nerve research is highly dynamic and a current major focus is the development of cell based supportive therapies as well as bioengineered nerve conduits to overcome the challenges in reconstructing long peripheral nerve defects. Whenever primary nerve repair cannot be performed without regeneration impairing tension at the suture sites, autologous nerve grafting or nerve tubulization...
متن کاملTiming and technique of peripheral nerve repair.
Surgery of the peripheral nerves is briefly reviewed with special emphasis on the timing and the techniques of nerve repair. The sooner a severed nerve can be repaired, the better the quality of the recovery. While delays of a few months after injury appear to have no serious effect on the out come of nerve sutures, the chances of successful recovery decline after six months. It is not common f...
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ژورنال
عنوان ژورنال: The Journal of Cell Biology
سال: 2017
ISSN: 0021-9525,1540-8140
DOI: 10.1083/jcb.201701082